Prothrombin Time tests the extrinsic coagulation pathway and is useful for detecting coagulation deficiencies, liver disease and disseminated intravascular coagulation (DIC). The prothrombin time (PT) is also the main monitor for coumarin therapy (e.g. warfarin), expressed as a ratio—the international normalized ratio (INR). The test measures the clotting time of plasma in the presence of a tissue extract, e.g. brain (thromboplastin). The test measures prothrombin but also factors V, VII, and X.
Sample: Citrate
Increase Prothrombin time
- Oral anticoagulation therapy (vitamin K antagonists)
- Fibrinogen deficiency (factor I)
- Prothrombin deficiency (factor II)
- Deficiency of factors V, VII or X (in V or X deficiency the activated partial thromboplastin time APTT will be increase)
- Liver disease especially obstructive
- Vitamin K deficiency
- DIC
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