Under U.S. Department of Transportation (DOT) and International Air Transport Association (IATA) regulations, all diagnostic specimens require triple packaging. This includes the following:
- Watertight primary containers made of glass, metal, or plastic with a positive (screw-on) cap.
- The primary container must be wrapped with enough absorbent material to be capable of absorbing all of its contents. Multiple specimens must be wrapped individually prior to placing them in the leak-proof secondary container.
- The secondary container is placed in a sturdy outer container made of corrugated fiberboard, wood, metal, or rigid plastic. An itemized list of contents in a sealed plastic bag is also placed in the outer container. Ice packs are placed between the secondary and the outer container. Additional measures must be taken when using ice and dry ice.
In January 2007, labeling of the outer container changed. The terms clinical specimen and diagnostic specimen have been replaced with biological substances, Category B. This wording is placed next to the label UN 3373.
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